Drug interactions
Amifampridine + Tramadol
Severity: Moderate
Amifampridine and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifampridine can cause dose-related seizures, and tramadol also lowers the seizure threshold. Using both may raise the risk of seizures.
What this interaction means in plain words
Amifampridine and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifampridine belongs to Central Nervous System; Tramadol belongs to Musculoskeletal.
Why it happens
Additive lowering of seizure threshold through different mechanisms.
What to do
Avoid the combination if possible, or use the lowest effective doses and monitor for seizure activity. Choose a non-proconvulsant analgesic when an alternative is suitable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Other interactions of Amifampridine
- Amifampridine + Bupropion-naltrexone Major
- Amantadine + Amifampridine Moderate
- Amifampridine + Amitriptyline Moderate
- Amifampridine + Baclofen Moderate
- Amifampridine + Bethanechol Moderate
- Amifampridine + Bromocriptine Moderate
Frequently asked questions
Can I take Amifampridine with Tramadol?
MediHelp rates the interaction as moderate. Amifampridine and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amifampridine can cause dose-related seizures, and tramadol also lowers the seizure threshold. Using both may raise the risk of seizures.
How serious is the interaction between Amifampridine and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, or use the lowest effective doses and monitor for seizure activity. Choose a non-proconvulsant analgesic when an alternative is suitable.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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