Drug interactions
Amifostine + Duloxetine
Severity: Moderate
Amifostine and Duloxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifostine commonly causes hypotension, and duloxetine can cause orthostatic hypotension and dizziness. Combined use may increase the risk of significant blood pressure drops. This matters because amifostine infusions are often given in patients who are volume depleted.
What this interaction means in plain words
Amifostine and Duloxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifostine belongs to Miscellaneous; Duloxetine belongs to Central Nervous System.
Why it happens
Additive hypotensive effects.
What to do
Monitor blood pressure before and during amifostine infusion and ensure adequate hydration. Consider whether duloxetine should be held in line with antihypertensive guidance for amifostine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Amifostine
Frequently asked questions
Can I take Amifostine with Duloxetine?
MediHelp rates the interaction as moderate. Amifostine and Duloxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amifostine commonly causes hypotension, and duloxetine can cause orthostatic hypotension and dizziness. Combined use may increase the risk of significant blood pressure drops. This matters because amifostine infusions are often given in patients who are volume depleted.
How serious is the interaction between Amifostine and Duloxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure before and during amifostine infusion and ensure adequate hydration. Consider whether duloxetine should be held in line with antihypertensive guidance for amifostine.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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