Drug interactions
Amifostine + Pentoxifylline
Severity: Moderate
Amifostine and Pentoxifylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifostine commonly causes hypotension, and pentoxifylline can lower blood pressure. Combined use may increase the risk of significant hypotension during amifostine infusion.
What this interaction means in plain words
Amifostine and Pentoxifylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifostine belongs to Miscellaneous; Pentoxifylline belongs to Cardiovascular.
Why it happens
Additive hypotensive effects through vasodilation and reduced peripheral resistance.
What to do
Monitor blood pressure before and during amifostine infusion, and consider holding pentoxifylline on the day of treatment. Ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pentoxifylline
- Fluoxetine + Pentoxifylline Moderate
- Fluvoxamine + Pentoxifylline Moderate
- Insulin degludec / insulin aspart + Pentoxifylline Moderate
- Methoxsalen + Pentoxifylline Moderate
- Mexiletine + Pentoxifylline Moderate
- Nifedipine + Pentoxifylline Moderate
Other interactions of Amifostine
Frequently asked questions
Can I take Amifostine with Pentoxifylline?
MediHelp rates the interaction as moderate. Amifostine and Pentoxifylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amifostine commonly causes hypotension, and pentoxifylline can lower blood pressure. Combined use may increase the risk of significant hypotension during amifostine infusion.
How serious is the interaction between Amifostine and Pentoxifylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure before and during amifostine infusion, and consider holding pentoxifylline on the day of treatment. Ensure adequate hydration.
What other medicines interact with Pentoxifylline?
MediHelp also lists interactions of Pentoxifylline with, for example, Fluoxetine, Fluvoxamine, Insulin degludec / insulin aspart. The full list is on the Pentoxifylline page.
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