Drug interactions
Fluvoxamine + Pentoxifylline
Severity: Moderate
Fluvoxamine and Pentoxifylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine is a strong CYP1A2 inhibitor and pentoxifylline and its metabolites are cleared partly via CYP1A2, so exposure to pentoxifylline may rise. Both drugs also affect platelet function, which can add to bleeding risk. Adverse effects such as nausea, dizziness and bleeding may be more likely.
What this interaction means in plain words
Fluvoxamine and Pentoxifylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Pentoxifylline belongs to Cardiovascular.
Why it happens
Fluvoxamine inhibits CYP1A2, and both drugs impair platelet function in an additive manner.
What to do
Monitor for bleeding and pentoxifylline adverse effects, and consider reducing the pentoxifylline dose if they occur. Watch more closely when other antithrombotics are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pentoxifylline
- Amifostine + Pentoxifylline Moderate
- Fluoxetine + Pentoxifylline Moderate
- Insulin degludec / insulin aspart + Pentoxifylline Moderate
- Methoxsalen + Pentoxifylline Moderate
- Mexiletine + Pentoxifylline Moderate
- Nifedipine + Pentoxifylline Moderate
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Pentoxifylline?
MediHelp rates the interaction as moderate. Fluvoxamine and Pentoxifylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluvoxamine is a strong CYP1A2 inhibitor and pentoxifylline and its metabolites are cleared partly via CYP1A2, so exposure to pentoxifylline may rise. Both drugs also affect platelet function, which can add to bleeding risk. Adverse effects such as nausea, dizziness and bleeding may be more likely.
How serious is the interaction between Fluvoxamine and Pentoxifylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and pentoxifylline adverse effects, and consider reducing the pentoxifylline dose if they occur. Watch more closely when other antithrombotics are used.
What other medicines interact with Pentoxifylline?
MediHelp also lists interactions of Pentoxifylline with, for example, Amifostine, Fluoxetine, Insulin degludec / insulin aspart. The full list is on the Pentoxifylline page.
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