Drug interactions
Methoxsalen + Pentoxifylline
Severity: Moderate
Methoxsalen and Pentoxifylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methoxsalen is a potent CYP1A2 inhibitor and pentoxifylline is partly cleared via CYP1A2. Oral methoxsalen may therefore raise pentoxifylline exposure and increase adverse effects such as nausea, flushing, dizziness and hypotension.
What this interaction means in plain words
Methoxsalen and Pentoxifylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methoxsalen belongs to Anti Fungals; Pentoxifylline belongs to Cardiovascular.
Why it happens
Methoxsalen inhibits CYP1A2-mediated metabolism of pentoxifylline.
What to do
Monitor for pentoxifylline adverse effects, including hypotension and bleeding, and reduce the dose if they appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pentoxifylline
- Amifostine + Pentoxifylline Moderate
- Fluoxetine + Pentoxifylline Moderate
- Fluvoxamine + Pentoxifylline Moderate
- Insulin degludec / insulin aspart + Pentoxifylline Moderate
- Mexiletine + Pentoxifylline Moderate
- Nifedipine + Pentoxifylline Moderate
Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Frequently asked questions
Can I take Methoxsalen with Pentoxifylline?
MediHelp rates the interaction as moderate. Methoxsalen and Pentoxifylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methoxsalen is a potent CYP1A2 inhibitor and pentoxifylline is partly cleared via CYP1A2. Oral methoxsalen may therefore raise pentoxifylline exposure and increase adverse effects such as nausea, flushing, dizziness and hypotension.
How serious is the interaction between Methoxsalen and Pentoxifylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for pentoxifylline adverse effects, including hypotension and bleeding, and reduce the dose if they appear.
What other medicines interact with Pentoxifylline?
MediHelp also lists interactions of Pentoxifylline with, for example, Amifostine, Fluoxetine, Fluvoxamine. The full list is on the Pentoxifylline page.
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