Drug interactions
Mexiletine + Pentoxifylline
Severity: Moderate
Mexiletine and Pentoxifylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mexiletine inhibits CYP1A2 and can increase exposure to methylxanthines such as pentoxifylline and its metabolites. This may cause nausea, tremor, palpitations, or other methylxanthine-type adverse effects.
What this interaction means in plain words
Mexiletine and Pentoxifylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mexiletine belongs to Cardiovascular; Pentoxifylline belongs to Cardiovascular.
Why it happens
Mexiletine inhibits CYP1A2 metabolism of pentoxifylline.
What to do
Monitor for nausea, tremor, tachycardia, and hypotension. Reduce the pentoxifylline dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mexiletine
- Fezolinetant + Mexiletine Contraindicated
- Mexiletine + Pimozide Contraindicated
- Alosetron + Mexiletine Major
- Amiodarone + Mexiletine Major
- Clozapine + Mexiletine Major
- Cobicistat + Mexiletine Major
Other interactions of Pentoxifylline
- Amifostine + Pentoxifylline Moderate
- Fluoxetine + Pentoxifylline Moderate
- Fluvoxamine + Pentoxifylline Moderate
- Insulin degludec / insulin aspart + Pentoxifylline Moderate
- Methoxsalen + Pentoxifylline Moderate
- Nifedipine + Pentoxifylline Moderate
Frequently asked questions
Can I take Mexiletine with Pentoxifylline?
MediHelp rates the interaction as moderate. Mexiletine and Pentoxifylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mexiletine inhibits CYP1A2 and can increase exposure to methylxanthines such as pentoxifylline and its metabolites. This may cause nausea, tremor, palpitations, or other methylxanthine-type adverse effects.
How serious is the interaction between Mexiletine and Pentoxifylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for nausea, tremor, tachycardia, and hypotension. Reduce the pentoxifylline dose if adverse effects occur.
What other medicines interact with Mexiletine?
MediHelp also lists interactions of Mexiletine with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Mexiletine page.
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