Drug interactions
Nifedipine + Pentoxifylline
Severity: Moderate
Nifedipine and Pentoxifylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentoxifylline has vasodilating and mild blood pressure lowering effects. Combined with nifedipine, it may enhance the hypotensive effect, particularly in patients on several antihypertensives.
What this interaction means in plain words
Nifedipine and Pentoxifylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nifedipine belongs to Cardiovascular; Pentoxifylline belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic vasodilation and blood pressure lowering.
What to do
Monitor blood pressure when starting or adjusting pentoxifylline in patients taking nifedipine. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Other interactions of Pentoxifylline
- Amifostine + Pentoxifylline Moderate
- Fluoxetine + Pentoxifylline Moderate
- Fluvoxamine + Pentoxifylline Moderate
- Insulin degludec / insulin aspart + Pentoxifylline Moderate
- Methoxsalen + Pentoxifylline Moderate
- Mexiletine + Pentoxifylline Moderate
Frequently asked questions
Can I take Nifedipine with Pentoxifylline?
MediHelp rates the interaction as moderate. Nifedipine and Pentoxifylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentoxifylline has vasodilating and mild blood pressure lowering effects. Combined with nifedipine, it may enhance the hypotensive effect, particularly in patients on several antihypertensives.
How serious is the interaction between Nifedipine and Pentoxifylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting or adjusting pentoxifylline in patients taking nifedipine. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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