Drug interactions
Amifostine + Risperidone
Severity: Moderate
Amifostine and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifostine commonly causes hypotension, and risperidone blocks alpha-1 receptors, which can add to the drop in blood pressure. Symptomatic hypotension or syncope may occur. The amifostine label advises considering withholding antihypertensive medicines before infusion.
What this interaction means in plain words
Amifostine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifostine belongs to Miscellaneous; Risperidone belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from amifostine and risperidone alpha-1 adrenergic antagonism.
What to do
Monitor blood pressure before and during amifostine infusion and ensure adequate hydration. Consider temporarily holding or adjusting other blood pressure-lowering drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Amifostine
Frequently asked questions
Can I take Amifostine with Risperidone?
MediHelp rates the interaction as moderate. Amifostine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amifostine commonly causes hypotension, and risperidone blocks alpha-1 receptors, which can add to the drop in blood pressure. Symptomatic hypotension or syncope may occur. The amifostine label advises considering withholding antihypertensive medicines before infusion.
How serious is the interaction between Amifostine and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure before and during amifostine infusion and ensure adequate hydration. Consider temporarily holding or adjusting other blood pressure-lowering drugs.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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