Drug interactions
Risperidone + Vandetanib
Severity: Contraindicated
Risperidone and Vandetanib: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vandetanib carries a boxed warning for QT prolongation, torsades de pointes and sudden death, and risperidone adds to this risk. The combination is best avoided.
What this interaction means in plain words
Risperidone and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Risperidone belongs to Central Nervous System; Vandetanib belongs to Oncology.
Why it happens
Additive QTc prolongation via cardiac potassium channel blockade.
What to do
Avoid concurrent use and select a non-QT-prolonging antipsychotic; if unavoidable, perform frequent ECG monitoring and keep potassium, magnesium and calcium normal.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
- Anagrelide + Risperidone Major
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Risperidone with Vandetanib?
MediHelp rates the interaction as contraindicated. Risperidone and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vandetanib carries a boxed warning for QT prolongation, torsades de pointes and sudden death, and risperidone adds to this risk. The combination is best avoided.
How serious is the interaction between Risperidone and Vandetanib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and select a non-QT-prolonging antipsychotic; if unavoidable, perform frequent ECG monitoring and keep potassium, magnesium and calcium normal.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Adagrasib, Amiodarone. The full list is on the Risperidone page.
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