Drug interactions
Amiodarone + Risperidone
Severity: Major
Amiodarone and Risperidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, and amiodarone may also raise risperidone concentrations through CYP2D6 inhibition. Together they increase the risk of torsades de pointes and other ventricular arrhythmias.
What this interaction means in plain words
Amiodarone and Risperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Risperidone belongs to Central Nervous System.
Why it happens
Additive QTc prolongation plus amiodarone inhibition of CYP2D6-mediated risperidone metabolism.
What to do
Avoid the combination where possible; if needed, obtain a baseline ECG and monitor QTc and electrolytes. Use the lowest effective risperidone dose and correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
- Anagrelide + Risperidone Major
Frequently asked questions
Can I take Amiodarone with Risperidone?
MediHelp rates the interaction as major. Amiodarone and Risperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QT interval, and amiodarone may also raise risperidone concentrations through CYP2D6 inhibition. Together they increase the risk of torsades de pointes and other ventricular arrhythmias.
How serious is the interaction between Amiodarone and Risperidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if needed, obtain a baseline ECG and monitor QTc and electrolytes. Use the lowest effective risperidone dose and correct potassium and magnesium.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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