Drug interactions
Ibutilide + Risperidone
Severity: Contraindicated
Ibutilide and Risperidone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibutilide strongly prolongs repolarization and carries a substantial risk of torsades de pointes. Risperidone adds further QT risk, so the combination is hazardous.
What this interaction means in plain words
Ibutilide and Risperidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ibutilide belongs to Cardiovascular; Risperidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation through potassium channel blockade.
What to do
Avoid the combination. If ibutilide is needed for cardioversion, use an alternative to risperidone or hold risperidone, with continuous ECG monitoring.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Risperidone
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
- Anagrelide + Risperidone Major
Other interactions of Ibutilide
- Amiodarone + Ibutilide Contraindicated
- Amisulpride + Ibutilide Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Clarithromycin + Ibutilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Dolasetron + Ibutilide Contraindicated
Frequently asked questions
Can I take Ibutilide with Risperidone?
MediHelp rates the interaction as contraindicated. Ibutilide and Risperidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ibutilide strongly prolongs repolarization and carries a substantial risk of torsades de pointes. Risperidone adds further QT risk, so the combination is hazardous.
How serious is the interaction between Ibutilide and Risperidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If ibutilide is needed for cardioversion, use an alternative to risperidone or hold risperidone, with continuous ECG monitoring.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Vandetanib, Adagrasib, Amiodarone. The full list is on the Risperidone page.
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