Drug interactions
Amifostine + Sotalol
Severity: Moderate
Amifostine and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifostine commonly causes hypotension, and sotalol can lower blood pressure and heart rate, so combined use may cause more severe or prolonged hypotension. At chemotherapeutic doses amifostine labeling advises withholding antihypertensives beforehand.
What this interaction means in plain words
Amifostine and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifostine belongs to Miscellaneous; Sotalol belongs to Cardiovascular.
Why it happens
Additive hypotensive effects (pharmacodynamic synergism).
What to do
Monitor blood pressure closely during amifostine infusion. At chemotherapeutic doses, hold antihypertensives for 24 hours beforehand where possible; if sotalol cannot be held, amifostine should not be given.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Amifostine
Frequently asked questions
Can I take Amifostine with Sotalol?
MediHelp rates the interaction as moderate. Amifostine and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amifostine commonly causes hypotension, and sotalol can lower blood pressure and heart rate, so combined use may cause more severe or prolonged hypotension. At chemotherapeutic doses amifostine labeling advises withholding antihypertensives beforehand.
How serious is the interaction between Amifostine and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely during amifostine infusion. At chemotherapeutic doses, hold antihypertensives for 24 hours beforehand where possible; if sotalol cannot be held, amifostine should not be given.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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