Drug interactions
Amikacin + Cefdinir
Severity: Minor
Amikacin and Cefdinir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a cephalosporin with an aminoglycoside may raise the risk of kidney injury, and amikacin itself is nephrotoxic and ototoxic. Oral cefdinir is not notably nephrotoxic, so the added risk is small and mostly relevant in patients with renal impairment or other risk factors.
What this interaction means in plain words
Amikacin and Cefdinir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amikacin belongs to Anti Bacterial; Cefdinir belongs to Anti Bacterial.
Why it happens
Possible additive nephrotoxicity, though not well established for oral cefdinir.
What to do
Monitor serum creatinine and amikacin levels as is routine for aminoglycoside therapy, and adjust the dose to renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefdinir
- Aluminum hydroxide + Cefdinir Moderate
- Cefdinir + Cholera vaccine Moderate
- Cefdinir + Famotidine Moderate
- Cefdinir + Gentamicin Moderate
- Cefdinir + Microbiota Moderate
- Cefdinir + Nizatidine Moderate
Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Cefdinir?
MediHelp rates the interaction as minor. Amikacin and Cefdinir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Combining a cephalosporin with an aminoglycoside may raise the risk of kidney injury, and amikacin itself is nephrotoxic and ototoxic. Oral cefdinir is not notably nephrotoxic, so the added risk is small and mostly relevant in patients with renal impairment or other risk factors.
How serious is the interaction between Amikacin and Cefdinir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and amikacin levels as is routine for aminoglycoside therapy, and adjust the dose to renal function.
What other medicines interact with Cefdinir?
MediHelp also lists interactions of Cefdinir with, for example, Aluminum hydroxide, Cholera vaccine, Famotidine. The full list is on the Cefdinir page.
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