Drug interactions
Amikacin + Lornoxicam
Severity: Moderate
Amikacin and Lornoxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs reduce renal prostaglandin-mediated perfusion and can lower glomerular filtration, which may raise aminoglycoside concentrations. This has been described mainly in neonates, but renal compromise from NSAIDs can also increase aminoglycoside nephrotoxicity in adults.
What this interaction means in plain words
Amikacin and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Lornoxicam belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal blood flow and aminoglycoside clearance.
What to do
Monitor amikacin trough levels and serum creatinine, especially in neonates, the elderly or dehydrated patients. Use a non-NSAID analgesic where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Other interactions of Lornoxicam
Frequently asked questions
Can I take Amikacin with Lornoxicam?
MediHelp rates the interaction as moderate. Amikacin and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs reduce renal prostaglandin-mediated perfusion and can lower glomerular filtration, which may raise aminoglycoside concentrations. This has been described mainly in neonates, but renal compromise from NSAIDs can also increase aminoglycoside nephrotoxicity in adults.
How serious is the interaction between Amikacin and Lornoxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor amikacin trough levels and serum creatinine, especially in neonates, the elderly or dehydrated patients. Use a non-NSAID analgesic where possible.
What other medicines interact with Amikacin?
MediHelp also lists interactions of Amikacin with, for example, Cidofovir, Adefovir, Amphotericin b. The full list is on the Amikacin page.
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