Drug interactions
Amikacin + Magnesium oxide
Severity: Minor
Amikacin and Magnesium oxide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amikacin can cause renal magnesium wasting and hypomagnesemia, so magnesium supplementation may be needed. The oral supplement does not itself raise aminoglycoside toxicity meaningfully.
What this interaction means in plain words
Amikacin and Magnesium oxide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amikacin belongs to Anti Bacterial; Magnesium oxide belongs to Gastrointestinal Tract.
Why it happens
Aminoglycoside-induced renal tubular magnesium loss.
What to do
Monitor serum magnesium during prolonged amikacin therapy and supplement if low.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Other interactions of Magnesium oxide
- Chloroquine + Magnesium oxide Moderate
- Ciprofloxacin + Magnesium oxide Moderate
- Dolutegravir + Magnesium oxide Moderate
- Doxycycline + Magnesium oxide Moderate
- Eltrombopag + Magnesium oxide Moderate
- Gemifloxacin + Magnesium oxide Moderate
Frequently asked questions
Can I take Amikacin with Magnesium oxide?
MediHelp rates the interaction as minor. Amikacin and Magnesium oxide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amikacin can cause renal magnesium wasting and hypomagnesemia, so magnesium supplementation may be needed. The oral supplement does not itself raise aminoglycoside toxicity meaningfully.
How serious is the interaction between Amikacin and Magnesium oxide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium during prolonged amikacin therapy and supplement if low.
What other medicines interact with Amikacin?
MediHelp also lists interactions of Amikacin with, for example, Cidofovir, Adefovir, Amphotericin b. The full list is on the Amikacin page.
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