Drug interactions
Amikacin + Oxaliplatin
Severity: Moderate
Amikacin and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can injure the kidney and the inner ear. Used together they may add to the risk of renal impairment and hearing or balance damage, which can be permanent. Oxaliplatin is less nephrotoxic than other platinum agents, but the aminoglycoside adds risk.
What this interaction means in plain words
Amikacin and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Oxaliplatin belongs to Oncology.
Why it happens
Additive nephrotoxicity and ototoxicity through separate toxic effects on renal tubular and cochlear cells.
What to do
Monitor serum creatinine and electrolytes during combined therapy and ask patients about hearing loss, tinnitus or vertigo. Use aminoglycoside dosing guided by levels and renal function, and choose a non-nephrotoxic antibiotic if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Amikacin with Oxaliplatin?
MediHelp rates the interaction as moderate. Amikacin and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can injure the kidney and the inner ear. Used together they may add to the risk of renal impairment and hearing or balance damage, which can be permanent. Oxaliplatin is less nephrotoxic than other platinum agents, but the aminoglycoside adds risk.
How serious is the interaction between Amikacin and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and electrolytes during combined therapy and ask patients about hearing loss, tinnitus or vertigo. Use aminoglycoside dosing guided by levels and renal function, and choose a non-nephrotoxic antibiotic if possible.
What other medicines interact with Amikacin?
MediHelp also lists interactions of Amikacin with, for example, Cidofovir, Adefovir, Amphotericin b. The full list is on the Amikacin page.
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