Drug interactions
Amiloride + Amoxicillin
Severity: Minor
Amiloride and Amoxicillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiloride has been reported to reduce the oral absorption of amoxicillin, possibly lowering antibiotic exposure. The effect is likely small and the evidence is limited.
What this interaction means in plain words
Amiloride and Amoxicillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiloride belongs to Cardiovascular; Amoxicillin belongs to Anti Bacterial.
Why it happens
Reduced gastrointestinal absorption of amoxicillin, mechanism not firmly established.
What to do
Separate doses by about 2 hours and monitor for reduced antibiotic response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amoxicillin
- Amoxicillin + Methotrexate Major
- Amoxicillin + Bcg vaccine live Moderate
- Amoxicillin + Cholera vaccine Moderate
- Amoxicillin + Eravacycline Moderate
- Amoxicillin + Microbiota Moderate
- Amoxicillin + Mycophenolate Moderate
Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Frequently asked questions
Can I take Amiloride with Amoxicillin?
MediHelp rates the interaction as minor. Amiloride and Amoxicillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amiloride has been reported to reduce the oral absorption of amoxicillin, possibly lowering antibiotic exposure. The effect is likely small and the evidence is limited.
How serious is the interaction between Amiloride and Amoxicillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate doses by about 2 hours and monitor for reduced antibiotic response.
What other medicines interact with Amoxicillin?
MediHelp also lists interactions of Amoxicillin with, for example, Methotrexate, Bcg vaccine live, Cholera vaccine. The full list is on the Amoxicillin page.
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