Drug interactions
Amoxicillin + Mycophenolate
Severity: Moderate
Amoxicillin and Mycophenolate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxicillin may lower mycophenolic acid exposure, particularly the late concentration peak, which can reduce immunosuppression. The effect is usually modest.
What this interaction means in plain words
Amoxicillin and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Gut flora alteration reduces deconjugation of mycophenolic acid glucuronide, impairing enterohepatic recirculation.
What to do
Monitor for graft rejection and consider mycophenolic acid level monitoring in high-risk patients during antibiotic therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amoxicillin
- Amoxicillin + Methotrexate Major
- Amoxicillin + Bcg vaccine live Moderate
- Amoxicillin + Cholera vaccine Moderate
- Amoxicillin + Eravacycline Moderate
- Amoxicillin + Microbiota Moderate
- Amoxicillin + Omadacycline Moderate
Frequently asked questions
Can I take Amoxicillin with Mycophenolate?
MediHelp rates the interaction as moderate. Amoxicillin and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxicillin may lower mycophenolic acid exposure, particularly the late concentration peak, which can reduce immunosuppression. The effect is usually modest.
How serious is the interaction between Amoxicillin and Mycophenolate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for graft rejection and consider mycophenolic acid level monitoring in high-risk patients during antibiotic therapy.
What other medicines interact with Amoxicillin?
MediHelp also lists interactions of Amoxicillin with, for example, Methotrexate, Bcg vaccine live, Cholera vaccine. The full list is on the Amoxicillin page.
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