Drug interactions
Amoxicillin + Cholera vaccine
Severity: Moderate
Amoxicillin and Cholera vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The oral cholera vaccine is a live attenuated strain that can be killed by active antibiotics, which may reduce the immune response. Protection may therefore be inadequate.
What this interaction means in plain words
Amoxicillin and Cholera vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity against the live attenuated Vibrio cholerae vaccine strain reduces its replication and immunogenicity.
What to do
Do not give the vaccine within 14 days of oral or parenteral antibiotic use, as per labeling. Delay vaccination until the antibiotic course is complete.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amoxicillin
- Amoxicillin + Methotrexate Major
- Amoxicillin + Bcg vaccine live Moderate
- Amoxicillin + Eravacycline Moderate
- Amoxicillin + Microbiota Moderate
- Amoxicillin + Mycophenolate Moderate
- Amoxicillin + Omadacycline Moderate
Frequently asked questions
Can I take Amoxicillin with Cholera vaccine?
MediHelp rates the interaction as moderate. Amoxicillin and Cholera vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The oral cholera vaccine is a live attenuated strain that can be killed by active antibiotics, which may reduce the immune response. Protection may therefore be inadequate.
How serious is the interaction between Amoxicillin and Cholera vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give the vaccine within 14 days of oral or parenteral antibiotic use, as per labeling. Delay vaccination until the antibiotic course is complete.
What other medicines interact with Amoxicillin?
MediHelp also lists interactions of Amoxicillin with, for example, Methotrexate, Bcg vaccine live, Eravacycline. The full list is on the Amoxicillin page.
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