Drug interactions
Amoxicillin + Bcg vaccine live
Severity: Moderate
Amoxicillin and Bcg vaccine live: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Live BCG is a viable bacterium, and an active antibiotic may reduce its viability in the host. Amoxicillin has limited activity against BCG, so the effect is mainly theoretical.
What this interaction means in plain words
Amoxicillin and Bcg vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity could reduce replication of the live attenuated organism, though amoxicillin activity against BCG is limited.
What to do
Where timing is flexible, give BCG after the antibiotic course is complete. Do not delay urgent vaccination solely because of amoxicillin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amoxicillin
- Amoxicillin + Methotrexate Major
- Amoxicillin + Cholera vaccine Moderate
- Amoxicillin + Eravacycline Moderate
- Amoxicillin + Microbiota Moderate
- Amoxicillin + Mycophenolate Moderate
- Amoxicillin + Omadacycline Moderate
Frequently asked questions
Can I take Amoxicillin with Bcg vaccine live?
MediHelp rates the interaction as moderate. Amoxicillin and Bcg vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Live BCG is a viable bacterium, and an active antibiotic may reduce its viability in the host. Amoxicillin has limited activity against BCG, so the effect is mainly theoretical.
How serious is the interaction between Amoxicillin and Bcg vaccine live?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where timing is flexible, give BCG after the antibiotic course is complete. Do not delay urgent vaccination solely because of amoxicillin.
What other medicines interact with Amoxicillin?
MediHelp also lists interactions of Amoxicillin with, for example, Methotrexate, Cholera vaccine, Eravacycline. The full list is on the Amoxicillin page.
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