Drug interactions
Amiloride + Bumetanide
Severity: Moderate
Amiloride and Bumetanide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bumetanide promotes potassium loss while amiloride retains potassium, so the two have opposing effects on serum potassium. The combination is often used deliberately to maintain potassium, but hyperkalemia can occur in renal impairment or with other potassium-raising drugs.
What this interaction means in plain words
Amiloride and Bumetanide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiloride belongs to Cardiovascular; Bumetanide belongs to Cardiovascular.
Why it happens
Opposing effects on renal potassium handling: loop diuretic kaliuresis versus ENaC blockade in the collecting duct.
What to do
Monitor serum potassium and renal function regularly, particularly after dose changes. Avoid potassium supplements unless hypokalemia is documented.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bumetanide
Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Frequently asked questions
Can I take Amiloride with Bumetanide?
MediHelp rates the interaction as moderate. Amiloride and Bumetanide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bumetanide promotes potassium loss while amiloride retains potassium, so the two have opposing effects on serum potassium. The combination is often used deliberately to maintain potassium, but hyperkalemia can occur in renal impairment or with other potassium-raising drugs.
How serious is the interaction between Amiloride and Bumetanide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function regularly, particularly after dose changes. Avoid potassium supplements unless hypokalemia is documented.
What other medicines interact with Bumetanide?
MediHelp also lists interactions of Bumetanide with, for example, Amifostine, Amikacin, Captopril-hydrochlorothiazide. The full list is on the Bumetanide page.
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