Drug interactions
Amiloride + Finerenone
Severity: Major
Amiloride and Finerenone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Finerenone is a mineralocorticoid receptor antagonist that raises serum potassium, and amiloride also conserves potassium. Used together they can cause clinically important hyperkalemia, particularly in patients with chronic kidney disease or diabetes.
What this interaction means in plain words
Amiloride and Finerenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiloride belongs to Cardiovascular; Finerenone belongs to Cardiovascular.
Why it happens
Additive potassium retention: finerenone blocks mineralocorticoid receptors while amiloride blocks collecting-duct ENaC.
What to do
Avoid the combination where possible; if used, check serum potassium and renal function frequently and adjust or interrupt finerenone according to its labeled potassium thresholds.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Amiloride with Finerenone?
MediHelp rates the interaction as major. Amiloride and Finerenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Finerenone is a mineralocorticoid receptor antagonist that raises serum potassium, and amiloride also conserves potassium. Used together they can cause clinically important hyperkalemia, particularly in patients with chronic kidney disease or diabetes.
How serious is the interaction between Amiloride and Finerenone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, check serum potassium and renal function frequently and adjust or interrupt finerenone according to its labeled potassium thresholds.
What other medicines interact with Amiloride?
MediHelp also lists interactions of Amiloride with, for example, Eplerenone, Spironolactone, Triamterene. The full list is on the Amiloride page.
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