Drug interactions
Finerenone + Posaconazole
Severity: Contraindicated
Finerenone and Posaconazole: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole substantially increases finerenone exposure, raising the risk of hyperkalemia and hypotension and worsening renal function.
What this interaction means in plain words
Finerenone and Posaconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Finerenone belongs to Cardiovascular; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole strongly inhibits CYP3A4, the main route of finerenone metabolism.
What to do
Do not use together; labeling contraindicates strong CYP3A4 inhibitors. If antifungal therapy is needed, hold finerenone for the course and check potassium before restarting.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Ritonavir Contraindicated
Frequently asked questions
Can I take Finerenone with Posaconazole?
MediHelp rates the interaction as contraindicated. Finerenone and Posaconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Posaconazole substantially increases finerenone exposure, raising the risk of hyperkalemia and hypotension and worsening renal function.
How serious is the interaction between Finerenone and Posaconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; labeling contraindicates strong CYP3A4 inhibitors. If antifungal therapy is needed, hold finerenone for the course and check potassium before restarting.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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