Drug interactions
Finerenone + Ketoconazole
Severity: Contraindicated
Finerenone and Ketoconazole: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole greatly increases finerenone exposure, raising the risk of hyperkalemia and renal effects. Finerenone labeling contraindicates strong CYP3A4 inhibitors.
What this interaction means in plain words
Finerenone and Ketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Finerenone belongs to Cardiovascular; Ketoconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition decreases the clearance of finerenone, a sensitive CYP3A4 substrate.
What to do
Do not use together. Interrupt finerenone during azole therapy or choose a non-interacting antifungal.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
- Finerenone + Ritonavir Contraindicated
Frequently asked questions
Can I take Finerenone with Ketoconazole?
MediHelp rates the interaction as contraindicated. Finerenone and Ketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketoconazole greatly increases finerenone exposure, raising the risk of hyperkalemia and renal effects. Finerenone labeling contraindicates strong CYP3A4 inhibitors.
How serious is the interaction between Finerenone and Ketoconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Interrupt finerenone during azole therapy or choose a non-interacting antifungal.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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