Drug interactions
Ensitrelvir + Finerenone
Severity: Contraindicated
Ensitrelvir and Finerenone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ensitrelvir increases finerenone exposure through CYP3A inhibition. This can cause hyperkalemia and renal function decline.
What this interaction means in plain words
Ensitrelvir and Finerenone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ensitrelvir belongs to Anti Virals; Finerenone belongs to Cardiovascular.
Why it happens
CYP3A inhibition reduces finerenone clearance.
What to do
Avoid the combination; use an alternative COVID-19 therapy and monitor potassium if finerenone must be interrupted or changed.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ensitrelvir
- Apalutamide + Ensitrelvir Contraindicated
- Carbamazepine + Ensitrelvir Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
- Ensitrelvir + Ivabradine Contraindicated
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
- Finerenone + Ritonavir Contraindicated
Frequently asked questions
Can I take Ensitrelvir with Finerenone?
MediHelp rates the interaction as contraindicated. Ensitrelvir and Finerenone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ensitrelvir increases finerenone exposure through CYP3A inhibition. This can cause hyperkalemia and renal function decline.
How serious is the interaction between Ensitrelvir and Finerenone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use an alternative COVID-19 therapy and monitor potassium if finerenone must be interrupted or changed.
What other medicines interact with Ensitrelvir?
MediHelp also lists interactions of Ensitrelvir with, for example, Apalutamide, Carbamazepine, Colchicine. The full list is on the Ensitrelvir page.
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