Drug interactions
Amiloride + Hydrochlorothiazide
Severity: Moderate
Amiloride and Hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The two drugs have opposing effects on potassium, and the combination is often used deliberately to preserve potassium. Hyperkalemia can still occur, especially in renal impairment, diabetes or older patients.
What this interaction means in plain words
Amiloride and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiloride belongs to Cardiovascular; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Thiazide-induced potassium loss is offset by amiloride blockade of epithelial sodium channels in the collecting duct, reducing potassium excretion.
What to do
Monitor serum potassium and renal function, particularly after starting and in patients at risk. Avoid additional potassium supplements unless hypokalemia is documented.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide
Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Frequently asked questions
Can I take Amiloride with Hydrochlorothiazide?
MediHelp rates the interaction as moderate. Amiloride and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The two drugs have opposing effects on potassium, and the combination is often used deliberately to preserve potassium. Hyperkalemia can still occur, especially in renal impairment, diabetes or older patients.
How serious is the interaction between Amiloride and Hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function, particularly after starting and in patients at risk. Avoid additional potassium supplements unless hypokalemia is documented.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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