Drug interactions
Amiloride + Sotalol
Severity: Moderate
Amiloride and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiloride can cause hyperkalemia, and sotalol is a non-selective beta-blocker that may blunt potassium shift into cells. Electrolyte disturbance is particularly relevant with sotalol because of its QT-prolonging and proarrhythmic potential.
What this interaction means in plain words
Amiloride and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiloride belongs to Cardiovascular; Sotalol belongs to Cardiovascular.
Why it happens
Amiloride reduces renal potassium excretion while beta-2 blockade by sotalol impairs cellular potassium uptake.
What to do
Monitor serum potassium, renal function and ECG including QT interval. Adjust amiloride if potassium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amiloride and Sotalol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Amiloride with Sotalol?
MediHelp rates the interaction as moderate. Amiloride and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiloride can cause hyperkalemia, and sotalol is a non-selective beta-blocker that may blunt potassium shift into cells. Electrolyte disturbance is particularly relevant with sotalol because of its QT-prolonging and proarrhythmic potential.
How serious is the interaction between Amiloride and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, renal function and ECG including QT interval. Adjust amiloride if potassium rises.
What other medicines interact with Amiloride?
MediHelp also lists interactions of Amiloride with, for example, Eplerenone, Spironolactone, Triamterene. The full list is on the Amiloride page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
