Drug interactions
Aminohippurate + Hydrochlorothiazide-irbesartan
Severity: Minor
Aminohippurate and Hydrochlorothiazide-irbesartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides compete for organic anion tubular secretion with aminohippurate, which could reduce its renal clearance. This may affect the accuracy of renal plasma flow measurement.
What this interaction means in plain words
Aminohippurate and Hydrochlorothiazide-irbesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular organic anion secretion.
What to do
Interpret effective renal plasma flow results with awareness of possible interference, or consider timing the test relative to diuretic doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Frequently asked questions
Can I take Aminohippurate with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as minor. Aminohippurate and Hydrochlorothiazide-irbesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazides compete for organic anion tubular secretion with aminohippurate, which could reduce its renal clearance. This may affect the accuracy of renal plasma flow measurement.
How serious is the interaction between Aminohippurate and Hydrochlorothiazide-irbesartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Interpret effective renal plasma flow results with awareness of possible interference, or consider timing the test relative to diuretic doses.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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