Drug interactions
Aminohippurate + Hydrochlorothiazide
Severity: Minor
Aminohippurate and Hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aminohippurate is used to measure renal plasma flow and is secreted by organic anion transporters in the proximal tubule. Thiazides are also secreted by this pathway and may compete, potentially altering test results.
What this interaction means in plain words
Aminohippurate and Hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for organic anion transporter-mediated tubular secretion.
What to do
Interpret renal plasma flow measurements with awareness of diuretic use, and consider holding the diuretic before testing if feasible.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Aminohippurate with Hydrochlorothiazide?
MediHelp rates the interaction as minor. Aminohippurate and Hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aminohippurate is used to measure renal plasma flow and is secreted by organic anion transporters in the proximal tubule. Thiazides are also secreted by this pathway and may compete, potentially altering test results.
How serious is the interaction between Aminohippurate and Hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Interpret renal plasma flow measurements with awareness of diuretic use, and consider holding the diuretic before testing if feasible.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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