Drug interactions
Amiodarone + Amlodipine-hydrochlorothiazide-valsartan
Severity: Moderate
Amiodarone and Amlodipine-hydrochlorothiazide-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone prolongs the QT interval, and thiazide-induced hypokalemia or hypomagnesemia increases the risk of torsades de pointes. Amiodarone also inhibits CYP3A4 and may modestly raise amlodipine levels, adding to hypotension or bradycardia.
What this interaction means in plain words
Amiodarone and Amlodipine-hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular.
Why it happens
Thiazide-induced electrolyte depletion potentiates amiodarone QT prolongation; amiodarone also weakly inhibits CYP3A4 metabolism of amlodipine.
What to do
Monitor potassium and magnesium and correct deficiencies, and obtain periodic ECGs. Watch for hypotension and bradycardia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp rates the interaction as moderate. Amiodarone and Amlodipine-hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone prolongs the QT interval, and thiazide-induced hypokalemia or hypomagnesemia increases the risk of torsades de pointes. Amiodarone also inhibits CYP3A4 and may modestly raise amlodipine levels, adding to hypotension or bradycardia.
How serious is the interaction between Amiodarone and Amlodipine-hydrochlorothiazide-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium and magnesium and correct deficiencies, and obtain periodic ECGs. Watch for hypotension and bradycardia.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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