Drug interactions
Amiodarone + Aripiprazole
Severity: Moderate
Amiodarone and Aripiprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may prolong the QT interval, and aripiprazole has a small QT effect. Amiodarone may also modestly raise aripiprazole exposure through CYP2D6 and CYP3A4 inhibition.
What this interaction means in plain words
Amiodarone and Aripiprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Aripiprazole belongs to Central Nervous System.
Why it happens
Additive QT effects and amiodarone-related inhibition of CYP2D6/CYP3A4 metabolism of aripiprazole.
What to do
Monitor ECG and electrolytes, and watch for aripiprazole adverse effects such as akathisia. Reduce the aripiprazole dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Amiodarone with Aripiprazole?
MediHelp rates the interaction as moderate. Amiodarone and Aripiprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone may prolong the QT interval, and aripiprazole has a small QT effect. Amiodarone may also modestly raise aripiprazole exposure through CYP2D6 and CYP3A4 inhibition.
How serious is the interaction between Amiodarone and Aripiprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, and watch for aripiprazole adverse effects such as akathisia. Reduce the aripiprazole dose if toxicity appears.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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