Drug interactions
Amiodarone + Atazanavir
Severity: Major
Amiodarone and Atazanavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir inhibits CYP3A4 and may raise amiodarone levels, and both drugs can prolong the PR or QT interval. This increases the risk of bradycardia, conduction block and torsades de pointes.
What this interaction means in plain words
Amiodarone and Atazanavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Atazanavir belongs to Anti Virals.
Why it happens
Atazanavir inhibits CYP3A4 metabolism of amiodarone, with additive effects on cardiac conduction and repolarization.
What to do
Avoid if possible; if combined, monitor ECG and amiodarone concentrations where available. Consider an alternative antiarrhythmic or antiretroviral.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Amiodarone with Atazanavir?
MediHelp rates the interaction as major. Amiodarone and Atazanavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir inhibits CYP3A4 and may raise amiodarone levels, and both drugs can prolong the PR or QT interval. This increases the risk of bradycardia, conduction block and torsades de pointes.
How serious is the interaction between Amiodarone and Atazanavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if combined, monitor ECG and amiodarone concentrations where available. Consider an alternative antiarrhythmic or antiretroviral.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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