Drug interactions
Bosutinib + Cisapride
Severity: Major
Bosutinib and Cisapride: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use may raise the risk of torsades de pointes. Cisapride has a restricted-use status because of this risk.
What this interaction means in plain words
Bosutinib and Cisapride can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bosutinib belongs to Oncology; Cisapride belongs to Gastrointestinal Tract.
Why it happens
Additive QT prolongation through cardiac potassium channel (hERG) blockade.
What to do
Avoid the combination where possible. If unavoidable, obtain baseline and follow-up ECGs and correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cisapride
- Apomorphine + Cisapride Contraindicated
- Artemether + Cisapride Contraindicated
- Azithromycin + Cisapride Contraindicated
- Ceritinib + Cisapride Contraindicated
- Chloroquine + Cisapride Contraindicated
- Cisapride + Citalopram Contraindicated
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Cisapride?
MediHelp rates the interaction as major. Bosutinib and Cisapride can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so combined use may raise the risk of torsades de pointes. Cisapride has a restricted-use status because of this risk.
How serious is the interaction between Bosutinib and Cisapride?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If unavoidable, obtain baseline and follow-up ECGs and correct potassium and magnesium.
What other medicines interact with Cisapride?
MediHelp also lists interactions of Cisapride with, for example, Apomorphine, Artemether, Azithromycin. The full list is on the Cisapride page.
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