Drug interactions
Amiodarone + Cabazitaxel
Severity: Moderate
Amiodarone and Cabazitaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone is a moderate CYP3A4 inhibitor and may increase cabazitaxel exposure, increasing the risk of neutropenia and other toxicity. It also prolongs the QT interval, though this is not a main concern with cabazitaxel.
What this interaction means in plain words
Amiodarone and Cabazitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Cabazitaxel belongs to Oncology.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein reduces cabazitaxel clearance.
What to do
Monitor blood counts closely and consider a cabazitaxel dose reduction if toxicity develops. Prefer an alternative antiarrhythmic if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Cabazitaxel
Frequently asked questions
Can I take Amiodarone with Cabazitaxel?
MediHelp rates the interaction as moderate. Amiodarone and Cabazitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone is a moderate CYP3A4 inhibitor and may increase cabazitaxel exposure, increasing the risk of neutropenia and other toxicity. It also prolongs the QT interval, though this is not a main concern with cabazitaxel.
How serious is the interaction between Amiodarone and Cabazitaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts closely and consider a cabazitaxel dose reduction if toxicity develops. Prefer an alternative antiarrhythmic if feasible.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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