Drug interactions
Amiodarone + Candesartan-hydrochlorothiazide
Severity: Moderate
Amiodarone and Candesartan-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone can prolong the QT interval and cause torsades de pointes, and thiazide-induced hypokalemia or hypomagnesemia increases that risk. Competition for renal tubular secretion is a minor additional effect.
What this interaction means in plain words
Amiodarone and Candesartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Candesartan-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Thiazide-induced electrolyte depletion potentiates amiodarone's QT-prolonging effect, with possible minor competition for renal tubular secretion.
What to do
Check serum potassium and magnesium at baseline and periodically, and correct deficits promptly. Obtain an ECG to monitor the QT interval.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amiodarone and Candesartan-hydrochlorothiazide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Candesartan-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Amiodarone and Candesartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone can prolong the QT interval and cause torsades de pointes, and thiazide-induced hypokalemia or hypomagnesemia increases that risk. Competition for renal tubular secretion is a minor additional effect.
How serious is the interaction between Amiodarone and Candesartan-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and magnesium at baseline and periodically, and correct deficits promptly. Obtain an ECG to monitor the QT interval.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
