Drug interactions
Amiodarone + Celecoxib
Severity: Minor
Amiodarone and Celecoxib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may raise celecoxib exposure because celecoxib is cleared mainly by CYP2C9. Higher celecoxib levels could increase the chance of gastrointestinal, renal or cardiovascular adverse effects, although the clinical impact is probably small.
What this interaction means in plain words
Amiodarone and Celecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiodarone belongs to Cardiovascular; Celecoxib belongs to Musculoskeletal.
Why it happens
Amiodarone and its metabolite inhibit CYP2C9, reducing celecoxib metabolism.
What to do
No routine dose change is needed; use the lowest effective celecoxib dose and watch for GI upset, edema or blood pressure rise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Celecoxib?
MediHelp rates the interaction as minor. Amiodarone and Celecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amiodarone may raise celecoxib exposure because celecoxib is cleared mainly by CYP2C9. Higher celecoxib levels could increase the chance of gastrointestinal, renal or cardiovascular adverse effects, although the clinical impact is probably small.
How serious is the interaction between Amiodarone and Celecoxib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; use the lowest effective celecoxib dose and watch for GI upset, edema or blood pressure rise.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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