Drug interactions
Amiodarone + Dapagliflozin-metformin
Severity: Minor
Amiodarone and Dapagliflozin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may inhibit renal cation transporters and modestly increase metformin exposure. The clinical effect is generally small but may matter in renal impairment.
What this interaction means in plain words
Amiodarone and Dapagliflozin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiodarone belongs to Cardiovascular; Dapagliflozin-metformin belongs to Endocrine.
Why it happens
Possible inhibition of OCT2/MATE-mediated renal secretion of metformin.
What to do
Monitor glycemic control and renal function; reduce metformin dose if gastrointestinal effects or reduced eGFR occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapagliflozin-metformin
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Dapagliflozin-metformin?
MediHelp rates the interaction as minor. Amiodarone and Dapagliflozin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amiodarone may inhibit renal cation transporters and modestly increase metformin exposure. The clinical effect is generally small but may matter in renal impairment.
How serious is the interaction between Amiodarone and Dapagliflozin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control and renal function; reduce metformin dose if gastrointestinal effects or reduced eGFR occur.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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