Drug interactions
Amiodarone + Dextromethorphan
Severity: Minor
Amiodarone and Dextromethorphan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone inhibits CYP2D6 and may raise dextromethorphan concentrations, increasing the chance of dizziness, drowsiness or confusion. The effect is usually modest at standard antitussive doses.
What this interaction means in plain words
Amiodarone and Dextromethorphan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiodarone belongs to Cardiovascular; Dextromethorphan belongs to Respiratory.
Why it happens
Inhibition of CYP2D6-mediated dextromethorphan metabolism by amiodarone.
What to do
Use standard antitussive doses and watch for dizziness or sedation; reduce the dextromethorphan dose if effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dextromethorphan
- Dextromethorphan + Isocarboxazid Contraindicated
- Dextromethorphan + Linezolid Contraindicated
- Dextromethorphan + Phenelzine Contraindicated
- Dextromethorphan + Rasagiline Contraindicated
- Dextromethorphan + Safinamide Contraindicated
- Dextromethorphan + Selegiline Contraindicated
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Dextromethorphan?
MediHelp rates the interaction as minor. Amiodarone and Dextromethorphan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amiodarone inhibits CYP2D6 and may raise dextromethorphan concentrations, increasing the chance of dizziness, drowsiness or confusion. The effect is usually modest at standard antitussive doses.
How serious is the interaction between Amiodarone and Dextromethorphan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use standard antitussive doses and watch for dizziness or sedation; reduce the dextromethorphan dose if effects occur.
What other medicines interact with Dextromethorphan?
MediHelp also lists interactions of Dextromethorphan with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Dextromethorphan page.
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