Drug interactions
Amiodarone + Diclofenac
Severity: Minor
Amiodarone and Diclofenac: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may inhibit CYP2C9 and so increase diclofenac exposure, potentially intensifying NSAID adverse effects such as GI, renal and cardiovascular events. The change is generally modest.
What this interaction means in plain words
Amiodarone and Diclofenac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiodarone belongs to Cardiovascular; Diclofenac belongs to Musculoskeletal.
Why it happens
Inhibition of CYP2C9-mediated diclofenac metabolism by amiodarone and its metabolite.
What to do
No routine adjustment is required. Use the lowest effective diclofenac dose and watch for NSAID-related adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Diclofenac?
MediHelp rates the interaction as minor. Amiodarone and Diclofenac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amiodarone may inhibit CYP2C9 and so increase diclofenac exposure, potentially intensifying NSAID adverse effects such as GI, renal and cardiovascular events. The change is generally modest.
How serious is the interaction between Amiodarone and Diclofenac?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is required. Use the lowest effective diclofenac dose and watch for NSAID-related adverse effects.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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