Drug interactions
Amiodarone + Dutasteride-tamsulosin
Severity: Moderate
Amiodarone and Dutasteride-tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone inhibits CYP3A4 and CYP2D6, both involved in tamsulosin and dutasteride metabolism, and may raise their concentrations. This could increase hypotension, dizziness and other adverse effects.
What this interaction means in plain words
Amiodarone and Dutasteride-tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Dutasteride-tamsulosin belongs to Genitourinary.
Why it happens
Amiodarone and its metabolite inhibit CYP2D6 and CYP3A4, decreasing clearance of tamsulosin and dutasteride.
What to do
Monitor blood pressure and orthostatic symptoms, especially after starting or changing amiodarone. Reduce the tamsulosin dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amiodarone and Dutasteride-tamsulosin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Dutasteride-tamsulosin
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Dutasteride-tamsulosin?
MediHelp rates the interaction as moderate. Amiodarone and Dutasteride-tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone inhibits CYP3A4 and CYP2D6, both involved in tamsulosin and dutasteride metabolism, and may raise their concentrations. This could increase hypotension, dizziness and other adverse effects.
How serious is the interaction between Amiodarone and Dutasteride-tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, especially after starting or changing amiodarone. Reduce the tamsulosin dose if adverse effects occur.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
