Drug interactions
Amiodarone + Duvelisib
Severity: Moderate
Amiodarone and Duvelisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib is a CYP3A4 inhibitor and can raise amiodarone exposure, while amiodarone may increase duvelisib exposure through P-glycoprotein inhibition and as a CYP3A4 substrate interaction. Higher amiodarone levels increase the risk of bradycardia, QT prolongation and other dose-related toxicity.
What this interaction means in plain words
Amiodarone and Duvelisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Duvelisib belongs to Oncology.
Why it happens
Duvelisib inhibits CYP3A4 (reducing amiodarone metabolism), and amiodarone inhibits P-glycoprotein efflux.
What to do
Monitor ECG and heart rate for signs of amiodarone excess, and watch for duvelisib adverse effects such as infection, diarrhea and rash. Reduce the amiodarone dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Amiodarone with Duvelisib?
MediHelp rates the interaction as moderate. Amiodarone and Duvelisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib is a CYP3A4 inhibitor and can raise amiodarone exposure, while amiodarone may increase duvelisib exposure through P-glycoprotein inhibition and as a CYP3A4 substrate interaction. Higher amiodarone levels increase the risk of bradycardia, QT prolongation and other dose-related toxicity.
How serious is the interaction between Amiodarone and Duvelisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and heart rate for signs of amiodarone excess, and watch for duvelisib adverse effects such as infection, diarrhea and rash. Reduce the amiodarone dose if toxicity appears.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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