Drug interactions
Amiodarone + Elacestrant
Severity: Moderate
Amiodarone and Elacestrant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may inhibit CYP3A4 and increase elacestrant exposure, which could raise adverse effects such as nausea and lipid abnormalities.
What this interaction means in plain words
Amiodarone and Elacestrant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Elacestrant belongs to Oncology.
Why it happens
Amiodarone inhibits CYP3A4-mediated metabolism of elacestrant.
What to do
Monitor for elacestrant adverse effects, noting that labeling advises avoiding strong and moderate CYP3A4 inhibitors where possible. Consider an alternative antiarrhythmic if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Elacestrant
Frequently asked questions
Can I take Amiodarone with Elacestrant?
MediHelp rates the interaction as moderate. Amiodarone and Elacestrant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone may inhibit CYP3A4 and increase elacestrant exposure, which could raise adverse effects such as nausea and lipid abnormalities.
How serious is the interaction between Amiodarone and Elacestrant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for elacestrant adverse effects, noting that labeling advises avoiding strong and moderate CYP3A4 inhibitors where possible. Consider an alternative antiarrhythmic if feasible.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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