Drug interactions
Amiodarone + Eltrombopag
Severity: Minor
Amiodarone and Eltrombopag: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may raise eltrombopag exposure, increasing the risk of dose-related liver toxicity. The interaction is predicted rather than well documented.
What this interaction means in plain words
Amiodarone and Eltrombopag have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiodarone belongs to Cardiovascular; Eltrombopag belongs to Miscellaneous.
Why it happens
Possible inhibition of CYP2C9 and CYP1A2 by amiodarone reducing eltrombopag clearance.
What to do
Monitor liver function tests and platelet counts, and adjust the eltrombopag dose as per the platelet response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Amiodarone with Eltrombopag?
MediHelp rates the interaction as minor. Amiodarone and Eltrombopag have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amiodarone may raise eltrombopag exposure, increasing the risk of dose-related liver toxicity. The interaction is predicted rather than well documented.
How serious is the interaction between Amiodarone and Eltrombopag?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests and platelet counts, and adjust the eltrombopag dose as per the platelet response.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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