Drug interactions
Amiodarone + Enalapril-hydrochlorothiazide
Severity: Moderate
Amiodarone and Enalapril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone prolongs the QT interval and thiazide-induced hypokalemia or hypomagnesemia increases the risk of torsades de pointes. The legacy suggestion of altered thiazide clearance is of little clinical importance compared with this electrolyte effect.
What this interaction means in plain words
Amiodarone and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Enalapril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Thiazide-induced hypokalemia and hypomagnesemia potentiate amiodarone-related QT prolongation.
What to do
Monitor potassium and magnesium and correct deficits. Obtain an ECG if other QT-prolonging drugs are present or if electrolytes are abnormal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Enalapril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Amiodarone and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone prolongs the QT interval and thiazide-induced hypokalemia or hypomagnesemia increases the risk of torsades de pointes. The legacy suggestion of altered thiazide clearance is of little clinical importance compared with this electrolyte effect.
How serious is the interaction between Amiodarone and Enalapril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium and magnesium and correct deficits. Obtain an ECG if other QT-prolonging drugs are present or if electrolytes are abnormal.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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