Drug interactions
Amiodarone + Fosinopril-hydrochlorothiazide
Severity: Moderate
Amiodarone and Fosinopril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide-induced hypokalemia and hypomagnesemia can increase the risk of QT prolongation and torsades de pointes in patients taking amiodarone. Any pharmacokinetic effect on renal clearance of hydrochlorothiazide is of minor importance.
What this interaction means in plain words
Amiodarone and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Fosinopril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Electrolyte depletion from the thiazide potentiates the QT-prolonging effect of amiodarone.
What to do
Monitor potassium and magnesium regularly and correct deficits, aiming for normal levels. Obtain an ECG if other QT-prolonging drugs are also used or symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Amiodarone and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide-induced hypokalemia and hypomagnesemia can increase the risk of QT prolongation and torsades de pointes in patients taking amiodarone. Any pharmacokinetic effect on renal clearance of hydrochlorothiazide is of minor importance.
How serious is the interaction between Amiodarone and Fosinopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium and magnesium regularly and correct deficits, aiming for normal levels. Obtain an ECG if other QT-prolonging drugs are also used or symptoms occur.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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