Drug interactions
Amobarbital + Guanfacine
Severity: Moderate
Amobarbital and Guanfacine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital can substantially lower guanfacine concentrations through CYP3A4 induction, reducing blood pressure or ADHD effect. Additive sedation may also occur.
What this interaction means in plain words
Amobarbital and Guanfacine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Guanfacine belongs to Cardiovascular.
Why it happens
CYP3A4 induction increases guanfacine metabolism.
What to do
Monitor blood pressure and clinical response and consider guanfacine dose increase per labeling; reduce the dose again if the inducer is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Guanfacine
- Clonidine + Guanfacine Major
- Guanfacine + Lofexidine Major
- Aldesleukin + Guanfacine Moderate
- Amiodarone + Guanfacine Moderate
- Amisulpride + Guanfacine Moderate
- Amitriptyline + Guanfacine Moderate
Frequently asked questions
Can I take Amobarbital with Guanfacine?
MediHelp rates the interaction as moderate. Amobarbital and Guanfacine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital can substantially lower guanfacine concentrations through CYP3A4 induction, reducing blood pressure or ADHD effect. Additive sedation may also occur.
How serious is the interaction between Amobarbital and Guanfacine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and clinical response and consider guanfacine dose increase per labeling; reduce the dose again if the inducer is stopped.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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