Drug interactions
Amiodarone + Hydrochlorothiazide-losartan
Severity: Moderate
Amiodarone and Hydrochlorothiazide-losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone inhibits CYP2C9 and CYP3A4, which may reduce conversion of losartan to its active metabolite and so blunt its blood pressure effect. Thiazide-induced hypokalemia or hypomagnesemia can also add to amiodarone's QT-prolonging and proarrhythmic potential.
What this interaction means in plain words
Amiodarone and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
Amiodarone inhibits CYP2C9/3A4-mediated formation of the active losartan metabolite E-3174, and hydrochlorothiazide-induced electrolyte loss adds to amiodarone QT prolongation.
What to do
Monitor blood pressure and adjust the losartan dose if the response is inadequate. Check potassium and magnesium regularly and correct deficits, and obtain an ECG if QT risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as moderate. Amiodarone and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone inhibits CYP2C9 and CYP3A4, which may reduce conversion of losartan to its active metabolite and so blunt its blood pressure effect. Thiazide-induced hypokalemia or hypomagnesemia can also add to amiodarone's QT-prolonging and proarrhythmic potential.
How serious is the interaction between Amiodarone and Hydrochlorothiazide-losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and adjust the losartan dose if the response is inadequate. Check potassium and magnesium regularly and correct deficits, and obtain an ECG if QT risk factors are present.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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