Drug interactions
Amiodarone + Imatinib
Severity: Moderate
Amiodarone and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib can prolong the QT interval and is a CYP3A4 substrate, while amiodarone inhibits CYP3A4 and P-glycoprotein. Imatinib exposure may rise and QT prolongation risk is additive.
What this interaction means in plain words
Amiodarone and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Imatinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein by amiodarone may raise imatinib levels, with additive QT effects.
What to do
Monitor ECG, electrolytes and imatinib adverse effects such as edema and cytopenias. Reduce the imatinib dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Amiodarone with Imatinib?
MediHelp rates the interaction as moderate. Amiodarone and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib can prolong the QT interval and is a CYP3A4 substrate, while amiodarone inhibits CYP3A4 and P-glycoprotein. Imatinib exposure may rise and QT prolongation risk is additive.
How serious is the interaction between Amiodarone and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, electrolytes and imatinib adverse effects such as edema and cytopenias. Reduce the imatinib dose if toxicity develops.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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