Drug interactions
Amiodarone + Ipratropium-salbutamol
Severity: Moderate
Amiodarone and Ipratropium-salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone markedly prolongs the QT interval and salbutamol can cause tachycardia, hypokalemia and arrhythmias, particularly at high doses. Together they may raise the risk of torsades de pointes or other ventricular arrhythmias.
What this interaction means in plain words
Amiodarone and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Ipratropium-salbutamol belongs to Respiratory.
Why it happens
Additive proarrhythmic effects: amiodarone QT prolongation plus beta-2 agonist induced hypokalemia and tachycardia.
What to do
Monitor ECG and serum potassium and magnesium, and correct deficits. Use the lowest effective salbutamol dose and avoid frequent high-dose nebulization.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Ipratropium-salbutamol?
MediHelp rates the interaction as moderate. Amiodarone and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone markedly prolongs the QT interval and salbutamol can cause tachycardia, hypokalemia and arrhythmias, particularly at high doses. Together they may raise the risk of torsades de pointes or other ventricular arrhythmias.
How serious is the interaction between Amiodarone and Ipratropium-salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and serum potassium and magnesium, and correct deficits. Use the lowest effective salbutamol dose and avoid frequent high-dose nebulization.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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