Drug interactions
Amiodarone + Isavuconazonium
Severity: Minor
Amiodarone and Isavuconazonium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole is a CYP3A4 substrate, and amiodarone is a weak CYP3A4 inhibitor, so isavuconazole exposure may modestly increase. Isavuconazole also shortens the QT interval, so QT effects are not additive.
What this interaction means in plain words
Amiodarone and Isavuconazonium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiodarone belongs to Cardiovascular; Isavuconazonium belongs to Anti Fungals.
Why it happens
Amiodarone weakly inhibits CYP3A4, reducing isavuconazole metabolism.
What to do
No routine adjustment is required; monitor for isavuconazole adverse effects such as liver enzyme elevations and gastrointestinal upset.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amiodarone and Isavuconazonium, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Amiodarone with Isavuconazonium?
MediHelp rates the interaction as minor. Amiodarone and Isavuconazonium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isavuconazole is a CYP3A4 substrate, and amiodarone is a weak CYP3A4 inhibitor, so isavuconazole exposure may modestly increase. Isavuconazole also shortens the QT interval, so QT effects are not additive.
How serious is the interaction between Amiodarone and Isavuconazonium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is required; monitor for isavuconazole adverse effects such as liver enzyme elevations and gastrointestinal upset.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
